David J. Augeri - Career Research Achievements - Synthetic Organic and Medicinal Chemistry and Drug Discovery

  1. UC-Irvine PhD, Synthetic Organic Chemistry - Prepared natural deoxypolypropionates using a novel hydrazone - mediated diastereoselective alkylation to generate 1,3-skipped alkyl chains.
  2. Princeton University NIH Postdoctoral Fellowship - Natural Product Synthesis - prepared calicheamicin oligosaccharide as recognition element and measured the DNA binding affinity.
  3. FDA Drug Discovery - AbbVie - Designed acylsulfonamide lead directly from a ternary NMR structure that launched the Venclexta (bcl-2, cancer) project to treat B-cell blood cancers.
  4. FDA Drug Discovery - Bristol-Myers Squibb, discovery of saxagliptin (Onglyza, DPP4 inhibitor, Type II Diabetes Mellitus, T2DM) with FDA Approval 2009.
  5. 3 INDs in 10 years with a talented group of 16 medicinal chemists from the best chemistry departments in the world (Princeton Univ, California Institute of Technology, Columbia Univ, Harvard Univ, Univ Texas-Austin, UC-Irvine, Stanford Univ, UC-Berkeley, Michigan Univ, Penn State, Ohio State). This group worked hard, asked excellent questions, taught me new things lots.
  1. Academic Funded Grant Proposals: During academics I wrote 7 grant proposals as co-PI that were funded. 5 NIH R01s, 1 DoD grant, 1 NIHR21. I collaborated with bio- professors who added me as a PI and allowed me to write a proposal with emphasis of the program shifted from studying a biologically active protein to developing a drug discovery program with that biologically active protein as the target and added the necessary scientists to the proposal to have impact on the programs.
  2. Publications: Published 47 peer-reviewed journal articles over my career, 11 as primary and/or corresponding author.
  3. Patents: I hold 63 issued US Patents and approximately two dozen published non-provisional applications.